Non-Hodgkin's lymphoma (NHL) is not a single disease but a general term used for a diverse group of up to 30 closely related cancers of the lymphatic system. Doctors categorize the many different types of NHL by the kind of cells (also called lymphocytes) that are abnormal, how fast they grow, and how they affect the body. In general, B-cell lymphomas start from abnormal B-cells, and T-cell lymphomas start from abnormal T-cells.
Non-Hodgkin's lymphoma can begin in any part of the lymphatic system, including the lymph nodes, special lymph organs such as the spleen, the bone marrow that makes lymphocytes, or in the lymph tissue of organs such as the stomach or intestines. Because lymphocytes are able to circulate to virtually every part of the body through the lymphatic system, NHL commonly spreads to different parts of the body. In fact, NHL is often present in more than one part of the body by the time it is diagnosed.
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- NHL is the seventh most common cancer in the United States
- Most cases of NHL occur in men and women over the age of 60
- By the end of 2009, approximately 66,000 new cases of NHL will be diagnosed
- Approximately 453,000 people are currently living with NHL
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There are two types of NHL: indolent and aggressive. Indolent NHL (also known as low-grade) is a type of NHL that grows slowly and usually causes fewer symptoms. Aggressive NHL (also known as intermediate- or high-grade) grows and spreads more quickly. During the course of the disease, some indolent forms of NHL can change into aggressive forms of NHL. The most common subtype of indolent NHL is follicular lymphoma. Knowing exactly what kind of NHL you have will help your doctor plan your treatment.
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